Jason is a 34-year-old married welder who has had some respiratory… Jason is a 34-year-old married welder who has had some respiratory problems for about 2 years that have gradually been getting worse. His family physician sent him to a pulmonologist when Jason’s chest X-ray came back “suspicious” for chronic obstructive pulmonary disease (COPD). The pulmonologist confirms that Jason does indeed have COPD. When asked about his smoking history, Jason reports that he smoked two packs of cigarettes daily from ages 19 through 24. He stopped smoking after the birth of his first child. When asked if others in his family have had COPD at any age, Jason says his adoptive father was diagnosed with COPD at the age of 70. He too was a smoker. Jason does not know anything about his birth parents. A blood test shows Jason to have low levels of alpha-1 antitrypsin (ATT). Genetic testing indicates that his alleles for the SERPINA1 gene are S/Z. Jason asks whether his children, now ages 10 and 6, are at risk and should be tested.The children may not be necessary to do genetic testing because the second-hand smoking, smoking, and environmental exposure to fumes that Jason has experienced since he was a young child. His adoptive father was also diagnosed with the same and it seems that the environment in his case has played a big role. I am trying to understand whether it is possible that Jason’s mutation can be somatic rather than germline and hence may not be transmitted to his progeny (Griffiths et al., 2000). Do you think it is possible that the mutation could have arose later in Jason’s life?┬áReferenceGriffiths, A. J., Miller, J. H., Suzuki, D. T., Lewontin, R. C., & Gelbart, W. M. (2000). Somatic versus germinal mutation. An introduction to genetic analysis.Health ScienceScienceNursing NURS MISC

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